Three dimensional cultures
In vitro cell-based assays are a powerful tool to investigate cellular mechanisms and a valuable model to study diseases and novel drugs. However, many current assays are performed using two-dimensional (2D) cell cultures, which, do not really mimic a real tissue structure.
Three-dimensional (3D) cell cultures, however, have the potential to overcome the limits of in vitro models by allowing cells to grow and establish physiological cell-cell and cell-substrate interactions in a 3D matrix, closer to the physiological cell organization within a tissue. 3D cultures can greatly improve the quality of research, whether it is cell-based drug screening, disease research or cell biology research. Moreover, they can reduce ethically- controversial animal testing.